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Who Wants to Feel Better?

I’ve spent most of my career studying how our biochemistry drives our behavior – how the foods we eat and the activities that we do change the way that we feel, look, and perform.

So, it’s with extreme pleasure that I’m able to announce that Amare Global will be pre-launching next month – and holding a kick-off event in Utah on August 25th & 26th.

Amare Global is “The Mental Health Company” – and our initial products pre-launching next month encompass a wide range of science-based natural solutions for improving vigor, mood, focus, energy, sleep, and overall well-being through balance of the microbiome and optimization of the gut-brain-axis.

See the flyer here = AmareUtah – I would love to see you there!

Here is a message from our Head of Sales, Rich Higbee:

Hello all Utah Friends:

Good news!  We’ve nailed down the location for the Utah Amare pre-launch event on Friday & Saturday, August 25thand 26th.  This is going to be a weekend that goes down in Amare history for sure. 

Details about the event are included in the attached flyer.  We’ve also created an Eventbrite registration link.  Space is limited and the event will likely sell out – so registration will be based on first come/first serve.  Please share this link with everyone you know and encourage them to get registered ASAP so they can guarantee a seat.

https://www.eventbrite.com/e/amare-global-visits-utah-august-25th-and-26th-tickets-36903936668

We can’t wait for Utah to hear the Amare story and learn about our incredible products, platform and mission around Mental Wellness.  Each Member of our Founding Executive Team will be joining us here in Utah – CEO Hiep Tran, CSO Dr. Shawn Talbott, CMO Mike Brown and myself (President of Sales) and Pat Hintze – our Founding Wellness Partner among other Amare Staff.  We can’t wait to see you and meet the people who join you at this momentous event.

See you soon.

Sincerely,

Rich Higbee

President Sales

Founding Executive

Amare Global

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Back to School Sleep Foods

It’s that time of year again – the final weeks of Summer have us thinking about getting ready to head back to school.

After a couple of months of late nights and lazy mornings, we need to get back into our rhythm of early to bed and early to rise – and that all starts with healthy sleep.

Maybe you’ve heard some of the advice to turn off electronics and read a real book for an hour before bed, but there are also diet tips that can help you relax and improve sleep quality.

Earlier this week, I visited the set of Fresh Living (KUTV CBS Channel 2 in Salt Lake City) to talk about some of my favorite foods and nutrients to help improve sleep – you can watch the video here.

Here are a few of my favorite foods and herbs that can help with sleep and relaxation:

Dairy: Warm milk’s calming quality is not just an old wives tale. Calcium and magnesium are relaxing. Plus milk has peptides (small protein chains) that, when digested, have direct relaxation effects in the brain. A glass of milk or cup of yogurt can be just the thing to relax the mind and help you slip off into a restful night of sleep

Whole grain carbohydrates: When you choose whole grains instead of refined grains, you maintain blood sugar levels, so your brain and body function better. Plus, the lignan compounds in whole grains are associated with lowered cortisol. Combine dairy and whole grains in a bedtime snack such as yogurt & granola or cheese and crackers.
Oranges: On the psychological side of stress, the scent of oranges and other citrus fruits has been shown to directly stimulate areas of the brain associated with stress resilience – so take a good whiff of orange to shield yourself from stress before you eat it. On the biochemical side of stress, oranges also contain both vitamin C and flavonoids, which are among the most effective nutrients for reducing concentrations of cortisol. In addition to cortisol control, flavonoids also help protect from other biological stressors such as free radicals and inflammatory cytokines that can lead to cellular damage and pain.

Cherries (especially tart cherries): have potent anti-inflammatory effects (to reduce pain) and naturally boost levels of melatonin (the sleep hormone) – making tart cherries one of the most effective foods to help athletes (and everyone) to relax and get a good night of sleep.
Almonds and Walnuts: Nuts are an excellent source of several anti-stress and sleep-enhancing nutrients including muscle-sparing protein, heart-healthy monounsaturated fats, stress-fighting B-vitamins and relaxing magnesium (mineral) and tryptophan (amino acid). Nuts also provide you with the opportunity to “crunch away” some of your stress because several studies have shown the chewing action to be associated with lower stress and better moods.

Corn grass: Perhaps the most effective natural herbal therapy that we’ve ever studied for improving both mood (due to increased serotonin production during the day) and sleep quality (due to increased melatonin production at night). Corn grass contains natural compounds that the body can convert into serotonin and melatonin “on demand” – so it won’t make you sleepy like melatonin (which is a synthetic version of your body’s natural hormone), but it will help you sleep when you’re ready (with no “melatonin hangover” the next day). Studies have shown corn grass extract to help reduce depression and anxiety, while also increasing both REM sleep (which rejuvenates the brain) and deep sleep (which restores the body).

Any (or all!) of these natural options can help you to relax and achieve the deepest most restorative sleep possible – which then gives you the clear mind and rejuvenated body to rise to the challenges of “back to school” or whatever life serves up!

Thanks for reading,

Shawn

====================================

Shawn M Talbott, PhD, CNS, LDN, FACSM, FAIS, FACN

Nutritional Biochemist and Author

(801) 915-1170 (mobile)

smtalbott@mac.com

www.shawntalbott.com

 

StressCookie.com – Herb-infused tea and cookies that improve vigor (physical energy, mental acuity, and emotional well-being)

 

Follow me on YouTube 

Follow me on Amazon 

Follow me on Twitter  

Follow me on LinkedIn 

Follow me on ShareCare 

Follow me on Facebook 

Follow me on  Facebook (Author page)

 

Best Future You – Harnessing Your Body’s Biochemistry to Achieve Balance in Body, Mind, and Spirit

The Secret of Vigor – How to Overcome Burnout, Restore Biochemical Balance, and Reclaim Your Natural Energy

Killer at Large – Why Obesity is America’s Greatest Threat – an award-winning documentary film exploring the causes and solutions underlying the American obesity epidemic

The Cortisol Connection – Why Stress Makes You Fat and Ruins Your Health (Hunter House)

The Cortisol Connection Diet – The Breakthrough Program to Control Stress and Lose Weight (Hunter House)

Cortisol Control and the Beauty Connection – The All-Natural Inside-Out Approach to Reversing Wrinkles, Preventing Acne, And Improving Skin Tone (Hunter House)

Natural Solutions for Pain-Free Living – Lasting Relief for Flexible Joints, Strong Bones and Ache-Free Muscles (Chronicle Publishers – Currant Books)

The Immune Miracle – The All-Natural Approach for Better Health, Increased Energy and Improved Mood (GLH Nutrition, 2012)

The Health Professionals Guide to Dietary Supplements (Lippincott, Williams & Wilkens)

A Guide to Understanding Dietary Supplements – an Outstanding Academic Text of 2004 (Haworth Press)

 

 

Psychological Vigor?

When people ask me what I do, I usually just say that I’m a “nutritionist” – it’s easier – and it’s usually enough at a party or networking event to get a nod, a smile, and a “very interesting” before moving on to the important stuff.

Every once in awhile, someone will ask, “what kind of nutrition?” – which allows me to explain that I’m trained in nutritional biochemistry (PhD Rutgers) and exercise physiology (MS Umass Amherst) – so I study how nutrition/exercise influence the body. Often, they’ll assume that I’m a “sports nutritionist” – and while I’m also a diplomate in sports nutrition with the International Olympic Committee (IOC), I don’t really “do” sports nutrition per se.

Rather, most of my research and writing (13 books) centers around how nutrition/exercise can change our biochemistry/physiology – and how those changes make us FEEL (psychology). I guess that makes me more of a pyscho-nutritional biochemist? Or a nutritional biopsychologist? Or maybe just a psycho?  ;^)

At any rate – whatever you call me – the work that I do is nicely encapsulated in the two audio files below. One is a 20-min Keynote lecture that I gave at a Behavioral Medicine conference a few years ago (Stress and Cortisol – Walking the Tight Rope) – and the other is a 90-min Tutorial from the same conference (Vigor 7 Days to Unlimited Energy, Focus, and Well-Being). The keynote is high-level and the tutorial gets into the details of stress physiology/biochemistry, nutrition/lifestyle interventions, and overall impact on psychological mood states such as vigor/burnout, depression, anxiety, and overall mental wellness.

If you’re curious about the inter-relationships between biochemistry, physiology, and psychology, then please take a listen and let me know your thoughts?

 

 

Thanks,

Shawn

 

Boost your Summer SPF (Sun-Protecting Foods)

During the hot summer months – it’s important to protect our skin from the damaging effects of the sun.

Watch the video = http://kutv.com/features/fresh-living/sun-protecting-foods

When most people think about “SPF” – they think about the sun protection factor as it relates to sunscreen.

As a nutritionist, I also like people to understand the “other SPF” – referring to “skin-protecting foods.”

These are foods that deliver specific nutrients that can help to block harmful UV light, reduce sunburns, and deliver a range of anti-aging benefits.

Some of my favorites are:

Carrots, cantaloupe, spinach and kale – are all high in beta-carotene that concentrates in the skin and protects from UV rays. Try one of my favorite smoothie recipes:

Green Acai (makes ~16oz)

  • 1⁄2 cup chopped kale (packed)
  • 1⁄2 cup chopped spinach (packed)
  • 1⁄4 avocado
  • 1 packet (3.5oz / 100g) of frozen acai berries
  • 1 cup coconut water
  • handful of parsley

Grapes, blueberries, and cherries – are all high in polyphenols that can help to reduce sun-induced oxidation (damage) to cells and DNA. Pop your fruit in the freezer so you can enjoy a frozen treat on a hot summer day.

Tomatoes and Watermelon – are high in lycopene, a red carotenoid that can significantly reduce sunburn risk – and either one can be used as the base for a healthy and delicious summer salad.

Salmon is high is astaxanthin – a carotenoid that can increase the natural SPF of your skin by the equivalent of 2-4 SPF sunscreen (from the inside)! At your next summer BBQ, skip the burger and fries in favor of a salmon burger (astaxanthin) and sweet potato (beta-carotene) for the ultimate in inside-out sun protection.

Eat as many of these foods as often as possible to protect your skin from the damaging effects of the summer sun.

Thanks for reading,

Shawn
====================================

Shawn M Talbott, PhD, CNS, LDN, FACSM, FAIS, FACN

Nutritional Biochemist and Author

(801) 915-1170 (mobile)

smtalbott@mac.com

www.shawntalbott.com

 

StressCookie.com – Herb-infused tea and cookies that improve vigor (physical energy, mental acuity, and emotional well-being)

 

Follow me on YouTube 

Follow me on Amazon 

Follow me on Twitter  

Follow me on LinkedIn 

Follow me on ShareCare 

Follow me on Facebook 

Follow me on  Facebook (Author page)

 

Best Future You – Harnessing Your Body’s Biochemistry to Achieve Balance in Body, Mind, and Spirit

The Secret of Vigor – How to Overcome Burnout, Restore Biochemical Balance, and Reclaim Your Natural Energy

Killer at Large – Why Obesity is America’s Greatest Threat – an award-winning documentary film exploring the causes and solutions underlying the American obesity epidemic

The Cortisol Connection – Why Stress Makes You Fat and Ruins Your Health (Hunter House)

The Cortisol Connection Diet – The Breakthrough Program to Control Stress and Lose Weight (Hunter House)

Cortisol Control and the Beauty Connection – The All-Natural Inside-Out Approach to Reversing Wrinkles, Preventing Acne, And Improving Skin Tone (Hunter House)

Natural Solutions for Pain-Free Living – Lasting Relief for Flexible Joints, Strong Bones and Ache-Free Muscles (Chronicle Publishers – Currant Books)

The Immune Miracle – The All-Natural Approach for Better Health, Increased Energy and Improved Mood (GLH Nutrition, 2012)

The Health Professionals Guide to Dietary Supplements (Lippincott, Williams & Wilkens)

A Guide to Understanding Dietary Supplements – an Outstanding Academic Text of 2004 (Haworth Press)

 

Curing Cancer This Weekend!

Kind of…

I’m riding my bike 140 miles in the Huntsman 140 on Saturday June 17 to raise money for cancer research.

If you can donate any amount, I’m still offering any of the great “prizes” (thank you gifts) that I wrote about here – or you can go directly to my donation page here.

I’m behind on my fundraising goal – so any amount is helpful – and I’ll be thinking of you on every pedal revolution!

$0.01 per mile = $1.40

$0.10 per mile = $14

$1.00 per mile = $140

Thanks!

Shawn

May is National Physical Fitness Month

In addition to May being “Mental Health Awareness” month, it is also designated as “Physical Fitness and Sports” month.

When we think about sports and physical fitness – we should always think about heart health – and on May 24, I visited Fresh Living on KUTV (Salt Lake City, CBS Ch2) to share a few of my favorite foods and supplements to improve heart health.

Video = http://kutv.com/features/fresh-living/healthy-foods-to-protect-your-heart

  1. Green tea and L-Theanine – reduce stress and blood pressure.
  2. Grapes and Grape seed flavonoids – lower cholesterol and improve blood flow.

Later this week, I’ll be presenting some new research related to cardiovascular fitness and astaxanthin at the American College of Sports Medicine Annual Scientific Conference in Denver.

Astaxanthin is a nutrient that many people have never heard of – but they should learn about it because it’s one of the most powerful heart health supplements out there.

Our study found a dramatic and significant improvement in cardiovascular efficiency with astaxanthin supplementation – so people who took the supplement (versus a placebo) were able to do more exercise with less “strain” on their heart.

  1. Wild Salmon, Shrimp, and Astaxanthin – reduce oxidation and improve heart efficiency.

I personally drink tea, eat grapes (and drink red wine), and eat wild salmon because they’re both delicious and heart-healthy, but I also increase my daily intake of these important nutrients with dietary supplements of Suntheanine (L-theanine), Enovita (grape seed extract), and AstaZine (astaxanthin).

For more information about the astaxanthin study, visit www.ShawnTalbott.com after the scientific presentation on June 2.

 

May is Mental Health Month!

In celebration of Mental Health Month during the month of May, I talked to the hosts of Fresh Living on Salt Lake City’s KUTV about the wide range of nutritional approaches to help improve mental health.

On April 29, I talked about a range of foods to help alleviate the “fatigue” that comes with disrupted mood = http://kutv.com/features/fresh-living/dr-shawn-talbott-nutrition-for-mental-wellness

On May 1, I talked about a simple 3-step approach to improving the communication between the gut-immune-brain axis, that can significantly boost our mental wellness and help us feel our best =  http://kutv.com/features/fresh-living/improving-mental-health-with-nutrition

Talking points from the May 1 show:

  1. Start with the Gut (the “2nd brain”) by restoring “good” bacteria with probiotics, prebiotics, and phytobiotics.
  2. Prime your immune system with “glucans” from yeast, mushrooms, and fatty acids from healthy fats.
  3. Tune up your brain and sharpen your mental focus with flavonoids from brightly colored fruits and vegetables (apples, grapes, pine bark).

Every aspect of how we feel and perform on a daily basis is influenced by our diet – including stress, mental focus, sleep quality, and even bigger issues such as depression and anxiety. It’s very likely to you – or someone you know – is affected by a mental wellness issue, which affects 1-in-5 of us! (and many experts feel that when you add in daytime fatigue and nighttime insomnia, it’s more like 1-in2 of us).

A recent research study shows just how impactful the right foods can literally be “curative” for epidemic diseases such as moderate to severe depression. Researchers from Australia looked at a Mediterranean-style diet (see below) – showing a significant reduction in depression indices – with more than a third of participants showing such dramatic changes that their depression was essentially gone – cured!

The diet used in the Australian study was approximately 40% carbs, 40% fat, and 20% protein primarily from whole grains, fruits/veggies, legumes, low-fat dairy, nuts, eggs, and lean meats (and limitations on sweets, sweetened beverages, refined grains, fast/fried foods, and processed meat). Of particular note, is that the diet was fairly high in fiber (15grams/day from fruits/veggies/legumes) and flavonoids (notably from red wine) – which may be delivering a prebiotic/psychobiotic anti-depressant effect mediated by the gut microbiome.

This is the very same style of diet regimen that has previously been shown to reduce heart disease, encourage weight loss, and prevent dementia – so now we can add anti-depressant effects to the list of health benefits of the Mediterranean diet. This food-mod connection is certainly meaningful for the millions of people who struggle with mental health issues everyday – from everyday bothers such as stress and insomnia – to more problematic issues such as depression and anxiety.

For the past 20 years or so, I’ve been studying how stress-induced imbalances can lead us to feel fat, fatigued, frazzled, unfocused, and general in a funk. However, restoring biochemical balance in the brain, the immune system, and the digestive system can help restore mental wellness. From my perspective in physiology (MS, exercise physiology) and biochemistry (PhD, nutritional biochemistry), I study how lifestyle (diet/exercise/sleep/stress/supplements) influences our psychology and behavior. In this way, I’m more of a “nutritional physio-psychologist”!?!? ;^)

Talking points from the April 29 show:

If you’re finding yourself stressed out, or if you can’t focus, or you find yourself low on energy, or in a bad mood, then you might consider adding certain foods and spices to your daily regiment to help dial up your mental wellness.

My nutritional approach to improving mental wellness and helping you feel better is multi- dimensional in nature and addresses many of the triggers that lead people to experience fatigue, including mood issues (depression/anxiety), brain fog (ADHD), and stress (cortisol/burnout).

There are many foods, herbs, and supplements (not to mention stress management, exercise, sleep patterns, etc) that can improve energy levels in this “multi-dimensional” way (for example, when you reduce depression/confusion/stress, the person often reports more “energy” and feelings of well-being).

Here are some examples of foods that I often recommend to help alleviate fatigue caused by various mood states:

Sad – coffee – go get a small latte with one shot of espresso (100mg of caffeine) and 1% milk. The combination of the stimulating caffeine plus the relaxing small peptides (protein chains) in the milk will help to increase neuron activity in the brain, without overstimulation – just enough to help you get out of a sour mood, but not enough to make you feel jittery and tense. Note = you need to stop at only one shot of espresso – consuming more caffeine will tip the scales towards tension/anxiety.

If you’re not a coffee drinker, then look for a new supplement called Whole Green Coffee Bean that combines a balanced blend of natural caffeine for energy, chlorogenic acids for blood sugar control, and polyphenols for brain protection – all bound to the natural coffee bean fiber – so you get long-lasting mental energy without the crash.

Unfocused – nuts, such as almonds and walnuts – and seeds, such as black cumin seed and pumpkin seed, contain healthy oils and other phytonutrients, that can induce a relaxation and anti-stress effect. The healthy fats in nut and seed oils can also to help protect the brain – and actually improve brain function. For example, black cumin seed oil has been show to increase brain power with improvements in focus. Memory, and overall cognition.

Tired – grapes and apple, which contain antioxidant compounds called OPCs (oligomeric proanthocyanins), can improve mental and physical energy levels. An even richer source of OPCs is New Zealand pine bark extract, which can be taken as a tea or a dietary supplement, and has been studied for improving “brain energy” and ADHD.

Stressed – prebiotics, which we normal get from high-fiber foods like fresh fruits and veggies and probiotics, which we think of finding in yogurt and fermented foods like kefir and kombucha – can also help to reduce stress, change our appetites (away from stress-induced sugar cravings), and improve our overall well-being. You’ve heard the term “gut-feeling” before – which refers to the “2nd brain” in our gut – the “enteric nervous system” that has as many neurons and produces as many neurotransmitters as the “1st brain” (in our heads)! Research is showing that keeping our guts balanced with pre-biotics and probiotics can help to maintain not just our intestinal function but also our brain function and overall mental wellness.

Bloated – Artichoke and Ginger are two of the best “digestive” aids to helping to maintain gut function and keep us from feeling overly full, bloated, and gassy. When we’re bloated or have indigestion, we can focus the way we want to and our energy levels are certainly sub-optimal. Just as pre/probiotics can help to maintain gut function in the “lower” gastrointestinal tract, artichoke and ginger can help to maintain optimal function of the upper and middle portion of the GI tract.

Anxious – green tea, contains the relaxing amino acid, Theanine, that induces a state of “relaxed alertness” where you feel “in the zone” with clear mental focus but also with a sense of peaceful calmness.

====================================

Shawn M Talbott, PhD, CNS, LDN, FACSM, FAIS, FACN

Nutritional Biochemist and Author

(801) 915-1170 (mobile)

smtalbott@mac.com

www.shawntalbott.com

 

StressCookie.com – Herb-infused tea and cookies that improve vigor (physical energy, mental acuity, and emotional well-being)

 

Follow me on YouTube 

Follow me on Amazon 

Follow me on Twitter  

Follow me on LinkedIn 

Follow me on ShareCare 

Follow me on Facebook 

Follow me on  Facebook (Author page)

 

Best Future You – Harnessing Your Body’s Biochemistry to Achieve Balance in Body, Mind, and Spirit

The Secret of Vigor – How to Overcome Burnout, Restore Biochemical Balance, and Reclaim Your Natural Energy

Killer at Large – Why Obesity is America’s Greatest Threat – an award-winning documentary film exploring the causes and solutions underlying the American obesity epidemic

The Cortisol Connection – Why Stress Makes You Fat and Ruins Your Health (Hunter House)

The Cortisol Connection Diet – The Breakthrough Program to Control Stress and Lose Weight (Hunter House)

Cortisol Control and the Beauty Connection – The All-Natural Inside-Out Approach to Reversing Wrinkles, Preventing Acne, And Improving Skin Tone (Hunter House)

Natural Solutions for Pain-Free Living – Lasting Relief for Flexible Joints, Strong Bones and Ache-Free Muscles (Chronicle Publishers – Currant Books)

The Immune Miracle – The All-Natural Approach for Better Health, Increased Energy and Improved Mood (GLH Nutrition, 2012)

The Health Professionals Guide to Dietary Supplements (Lippincott, Williams & Wilkens)

A Guide to Understanding Dietary Supplements – an Outstanding Academic Text of 2004 (Haworth Press)

 

 

Synbiotics Reduce Oxidative Stress

Yet another example of how keeping the gut microbiome healthy – in this case with a “synbiotic” combination of probiotic and prebiotic – also keeps the rest of the body healthy (reduced oxidative stress and cellular damage).

Oxid Med Cell Longev. 2017;2017:9315375. doi: 10.1155/2017/9315375. Epub 2017 Feb 13.

Influence of Synbiotics on Selected Oxidative Stress Parameters.

Abstract

The aim of the present study was to assess synbiotic (Lactobacillus casei + inulin) influence on oxidative stress parameters such as concentrations of malondialdehyde (MDA), hydrogen peroxide (H2O2), glutathione, and free sulfhydryl groups content. Experiments were carried out on healthy volunteers (n = 32). The subjects were divided into women group (n = 16) and men group (n = 16) and randomly assigned to synbiotic and control groups. Blood samples were collected before synbiotic supplementation and after 7 wks, at the end of the study. The administration of synbiotic resulted in a significant decrease in MDA (p < 0.01), H2O2 (p < 0.01), and GSSG concentrations (p < 0.05) as compared with the control groups and significant increase in the concentrations of GSHt (p < 0.001), GSH (p < 0.01), and -SH group content (p < 0.05) versus control. Synbiotics containing L. casei plus inulin may have positive influence on selected oxidative stress markers.

PMID:

 

28286605

 

PMCID:

 

PMC5327756

 

DOI:

 

10.1155/2017/9315375

Polyphenols & Microbiome…

I’m giving a short talk and participating in an expert panel discussion at UC Davis next week, where I will talk about, “Gut Feelings – the Role of the Microbiome in Mental Wellness” – and touch on aspects of dietary supplements related to probiotics, prebiotics, and “phytobiotics” like polyphenols that can modulate (and be modulated by) our microbiome.

Here is an interesting recent paper on the topic…

Biochem Pharmacol. 2017 Mar 16. pii: S0006-2952(17)30141-7. doi: 10.1016/j.bcp.2017.03.012.

Role of the small intestine, colon and microbiota in determining the metabolic fate of polyphenols.

Abstract

(Poly)phenols are a large group of compounds, found in food, beverages, dietary supplements and herbal medicines. Owing to their biological activities, absorption and metabolism of the most abundant compounds in humans are well understood. Both the chemical structure of the phenolic moiety and any attached chemical groups define whether the polyphenol is absorbed in the small intestine, or reaches the colon and is subject to extensive catabolism by colonic microbiota. Untransformed substrates may be absorbed, appearing in plasma primarily as methylated, sulfated and glucuronidated derivatives, with in some cases the unchanged substrate. Many of the catabolites are well absorbed from the colon and appear in the plasma either similarly conjugated, or as glycine conjugates, or in some cases unchanged. Although many (poly)phenol catabolites have been identified in human plasma and / or urine, the pathways from substrate to final catabolite, and the species of bacteria and enzymes involved, are still scarcely reported. While it is clear that the composition of the human gut microbiota can be modulated in vivo by supplementation with some (poly)phenol-rich commodities, such modulation is definitely not an inevitable consequence of supplementation, it depends on the treatment, length of time and on the individual metabotype, and it is not clear whether the modulation is sustained when supplementation ceases. Some catabolites have been recorded in plasma of volunteers at concentrations similar to those shown to be effective in in vitro studies suggesting that some benefit may be achieved in vivo by diets yielding such catabolites.

KEYWORDS: Bioavailability; Conjugation; Microbiota; Phenolic acids; Polyphenols

PMID: 28322745 DOI: 10.1016/j.bcp.2017.03.012

Stress, Overeating, and Obesity?

Neurosci Biobehav Rev. 2017 Mar 11. pii: S0149-7634(16)30394-3. doi: 10.1016/j.neubiorev.2017.01.026.

Stress, overeating, and obesity: Insights from human studies and preclinical models.

Abstract

Eating disorders and obesity have become predominant in human society. Their association to modern lifestyle, encompassing calorie-rich diets, psychological stress, and comorbidity with major diseases are well documented. Unfortunately the biological basis remains elusive and the pharmacological treatment inadequate, in part due to the limited availability of valid animal models. Human research on binge eating disorder (BED) proves a strong link between stress exposure and bingeing: state-levels of stress and negative affect are linked to binge eating in individuals with BED both in laboratory settings and the natural environment. Similarly, classical animal models of BED reveal an association between acute exposure to stressors and binging but they are often associated with unchanged or decreased body weight, thus reflecting a negative energy balance, which is uncommon in humans where most commonly BED is associated with excessive or unstable body weight gain. Recent mouse models of subordination stress induce spontaneous binging and hyperphagia, altogether more closely mimicking the behavioral and metabolic features of human BED. Therefore the translational relevance of subordination stress models could facilitate the identification of the neurobiological basis of BED and obesity-associated disease and inform on the development of innovative therapies.

KEYWORDS: Animal model; Chronic subordination stress; Ecological momentary assessment; Negative affect; Social stress; Stress

PMID: 28292531
DOI: 10.1016/j.neubiorev.2017.01.026
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