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Probiotics and Depression

In an outstanding scientific review from Caroline Wallace and Roumen Milev at Queen’s University in Ontario Canada, the effects of probiotics on depressive symptoms in humans is reviewed = https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319175/

Some highlights from the publication:

  • link between psychiatric disorders and changes in the microbiome
  • majority of the studies found positive results on all measures of depressive symptoms (depending on the specific strain or probiotic, dosing and duration)
  • evidence for probiotics alleviating depressive symptoms is compelling
  • probiotics may reduce depression and improve mood via a variety of complementary mechanisms, including:
    • modulation of stress response
    • increased neurotransmitter production and improved activity
    • reduction in permeability of gastrointestinal lining
    • increased production of brain-derived neurotrophic factor (BDNF), a growth factor crucial for brain plasticity, memory, and neuronal health
    • Reduction in both gastrointestinal inflammation  and neuro-inflammation

Abstract:

Ann Gen Psychiatry. 2017; 16: 14.

The effects of probiotics on depressive symptoms in humans: a systematic review

 

 

Background

Patients suffering from depression experience significant mood, anxiety, and cognitive symptoms. Currently, most antidepressants work by altering neurotransmitter activity in the brain to improve these symptoms. However, in the last decade, research has revealed an extensive bidirectional communication network between the gastrointestinal tract and the central nervous system, referred to as the “gut–brain axis.” Advances in this field have linked psychiatric disorders to changes in the microbiome, making it a potential target for novel antidepressant treatments. The aim of this review is to analyze the current body of research assessing the effects of probiotics, on symptoms of depression in humans.

Methods

A systematic search of five databases was performed and study selection was completed using the preferred reporting items for systematic reviews and meta-analyses process.

Results

Ten studies met criteria and were analyzed for effects on mood, anxiety, and cognition. Five studies assessed mood symptoms, seven studies assessed anxiety symptoms, and three studies assessed cognition. The majority of the studies found positive results on all measures of depressive symptoms; however, the strain of probiotic, the dosing, and duration of treatment varied widely and no studies assessed sleep.

Conclusion

The evidence for probiotics alleviating depressive symptoms is compelling but additional double-blind randomized control trials in clinical populations are warranted to further assess efficacy.

Keywords: Depression, Anxiety, Probiotics, Gut–brain axis, Microbiome, Systematic review

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Microbiome and Stress/Anxiety Regulation

Very interesting new paper from the APC Microbiome Institute at University College in Cork Ireland = https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-017-0321-3

This paper made some important strides in identifying the undying mechanisms for the microbiome in our gut (our 2nd brain) to “talk” to the areas of the 1st brain in our heads involved in anxiety, stress, and fear (amygdala and pre-frontal cortex) –  via microRNAs (miRNAa) that act through translational repression to control gene translation and have also been implicated in anxiety-like behaviors.

Highlights from the paper:

  • growing evidence for a role of the gut microbiome in shaping behavior relevant to many psychiatric and neurological disorders
  • it’s been repeatedly demonstrated that manipulation of the gut microbiome modulates anxiety-like behaviors
  • certain probiotics and prebiotics have anxiolytic-like activity (anti-anxiety)
  • potential of microbiota-mediated therapeutic approaches for treating anxiety-related disorders

Here is the Abstract from the publication:

Microbial regulation of microRNA expression in the amygdala and prefrontal cortex

Microbiome 2017 5:102

Published: 25 August 2017

Abstract

Background

There is growing evidence for a role of the gut microbiome in shaping behaviour relevant to many psychiatric and neurological disorders. Preclinical studies using germ-free (GF) animals have been essential in contributing to our current understanding of the potential importance of the host microbiome for neurodevelopment and behaviour. In particular, it has been repeatedly demonstrated that manipulation of the gut microbiome modulates anxiety-like behaviours. The neural circuits that underlie anxiety- and fear-related behaviours are complex and heavily depend on functional communication between the amygdala and prefrontal cortex (PFC). Previously, we have shown that the transcriptional networks within the amygdala and PFC of GF mice are altered. MicroRNAs (miRNAs) act through translational repression to control gene translation and have also been implicated in anxiety-like behaviours. However, it is unknown whether these features of host post-transcriptional machinery are also recruited by the gut microbiome to exert control over CNS transcriptional networks.

Results

We conducted Illumina® next-generation sequencing (NGS) in the amygdala and PFC of conventional, GF and germ-free colonized mice (exGF). We found a large proportion of miRNAs to be dysregulated in GF animals in both brain regions (103 in the amygdala and 31 in the PFC). Additionally, colonization of GF mice normalized some of the noted alterations. Next, we used a complementary approach to GF by manipulating the adult rat microbiome with an antibiotic cocktail to deplete the gut microbiota and found that this strategy also impacted the expression of relevant miRNAs.

Conclusion

These results suggest that the microbiome is necessary for appropriate regulation of miRNA expression in brain regions implicated in anxiety-like behaviours.

Keywords

Amygdala Prefrontal cortex Microbiome-gut-brain axis MicroRNAs Germ-free Antibiotics miR-206-3p

Amare Product Training

On Sept 14, 2017 – I had the great pleasure to join Amare Global’s Founding Wellness Partner, Pat Hintze to present an overview of the Amare product lineup.

Just entering our second week of pre-launch (we went “live” on Sept 1), we had almost 100 attendees to hear about how Amare is changing the way the world approaches Mental Wellness (by rebalancing the microbiome and gut-brain-axis). We expect close to 500 people at our Pre-Launch Summit in Irvine CA this coming Saturday (Sept 23) – and if you’re anywhere near Orange County, then you NEED to get yourself there!

If you’re interested, you can use the links below to view the slides and listen to the audio of my presentation in Wisconsin:

Slides (PDF version) = Amare Wisconsin 091417

Audio file (mp4 format – will play in iTunes) =

Please let me know any questions or comments?

Mind-Gut Connection in Irvine Sept 23!

I’m thrilled to announce that Emeran Mayer, MD, PhD will be speaking at our Amare Pre-Launch Summit this coming Saturday (Sept 23) in Irvine CA.

Please see attached flyer below for all the details.

If you’re in the Orange County area and you care about your mental wellness and overall health, then you HAVE to make a it a priority to be at this meeting.

Emeran Mayer, Amare Scientific Advisory Board Member – pioneer of gut-brain axis research and author ofThe Mind-Gut Connection will be a featured speaker at the event!  Dr. Mayer is a Gastroenterologist, Neuroscientist and Professor in the
Departments of Medicine, Physiology and Psychiatry at the David Geffen School of Medicine
at UCLA.  As one of the pioneers and leading researchers in the role of mind-brain-gut interactions in health and chronic disease, Dr. Mayer has been interviewed on National Public Radio, PBS and by many national and international media outlets including the Los Angeles Times, Atlantic magazine, Time and Newsweek Magazine and National Geographic Explorer.  He has spoken at UCLA TEDx on the Mysterious Origins of Gut Feelings in 2015, and his book The Mind Gut Connection has been published by HarperCollins in July of 2016 and has been translated into 14 languages.

The first 300 guests to arrive to the event on Saturday at the Irvine Marriott receive a FREE product!

Running Training Week 3

OK – 3rd week of the running training…

Your GOAL this coming week is EXACTLY the same as last week (I know – “boring” – but “effective” for getting your stronger/faster in these early first weeks)!

NEXT week will lead us into week FOUR where we will switch things up to keep your muscles and lungs adapting at the proper rate (we’ll also discuss NUTRITION next week in a podcast/audio).

Just like the last 2 weeks, we want you to complete at least THREE specific workouts:

  • one “interval” workout…
  • one “hill” workout…
  • one “endurance” workout (LSD = long slow distance)

Remember that the objective of intervals is to make you faster – the objective of hills is to make you stronger – and the objective of LSD is to improve your endurance and fat-burning efficiency.

Here is WEEK 3:

  • Sat Sept 16 or Sun Sept 17:
    • 60-70 minute Long Slow Distance (LSD) – “endurance”
      • RPE (rating of perceived exertion) = 5-7 (out of 10)
  • Mon Sept 18 or Tues Sept 19:
    • 1 mile easy jog to warm-up
    • 6-7 Intervals – “speed”
    • 60-seconds “fast” (RPE = 7-9)
    • 60-seconds “slow” (RPE (2-3)
      • NOTE = be sure to go hard / easy – NOT “medium”
    • 1 mile easy jog to cool-down
      • NOTE = this is only 6-7 minutes of “hard” effort – so if you want a longer workout, you can run additional “tempo” miles to your level of fitness.
  • Wed Sept 20 or Thurs Sept 21:
    • 1 mile easy jog to warm-up
    • 6-7 Hills – “strength”
    • 60-seconds per UPhill (RPE = 7-9)
    • 60-seconds per DOWNhill (RPE = 2-3)
      • NOTE = be sure to go hard / easy – NOT “medium”
    • 1 mile easy jog to cool-down
      • NOTE = this is only 6-7 minutes of “hard” effort – so if you want a longer workout, you can run additional “tempo” miles to your level of fitness.

Tempo workouts are those “medium hard” efforts that leave us feeling like we had a “good workout” – but they’re not very effective for actual “performance” – so we prefer to run tempo pace (RPE = 6-7) when we want to loosen the legs + free the mind (not for our 3 specific training sessions each week.

That’s all for now – please send Shawn and Julie any questions – and Good Luck training!

Amare Visits Milwaukee!

This coming Thursday, Sept 14 – Amare Global, The Mental Wellness Company, will be visiting Milwaukee WI to spread our message about the new paradigm of harnessing the microbiome and the gut-brain-axis to improve mental wellness.

We’ll be at the Olympia Resort in Oconomowoc (1350 Royale Mile Rd., Oconomowoc, WI 53066) from 7-8:30pm (see flyer below).

We’ll be talking about how “mental wellness” is misunderstood by most people – and how the new science of the microbiome (gut bacteria) and gut-brain-axis can help us to modulate our own levels of happiness, energy, focus, and motivation.

We would love to see you there!

Amare Milwaukee Flyer (PDF)

Amare Milwaukee Flyer

Toward a new mental wellness paradigm

Amare Global, The Mental Wellness Company is hosting TWO FREE events in Irvine CA:

  • Friday, September 22nd (6-10pm) – Pre-Launch Ribbon Cutting
    • At our new offices (17871 Gillette Ave, Irvine, CA)
    • Food, Ribbon-cutting, music/dancing, tours, photos

 

  • Saturday, September 23rd (9am-5pm) – Pre-Launch Summit
    • Irvine Marriott (18000 Von Karman Ave, Irvine, CA)
    • Hear the story that brought the founding executives together to form the Mental Wellness Company
    • Learn from Amare CSO, Dr. Shawn Talbott about the Amare Mental Wellness Products
    • Find out why CEO Hiep Tran wants to build the world’s most comprehensive Mental Wellness Platform
    • Learn from President of Sales Rich Higbee about Servant Leadership and the Amare Culture
    • Discover from CMO Mike Brown about the marketing tools available to help you share Amare
    • Hear from Founding Wellness Partner Pat Hintze about the Strive for Life Success System
    • Get a chance to PRACTICE your own Mental Wellness Techniques

 

See more on FaceBook = https://www.facebook.com/events/1908494066070345/

Register here = https://www.eventbrite.com/e/amare-global-pre-launch-summit-tickets-37462444179?aff=efbeventtix

Please see the Event Flyer (PDF) = LaunchEvent_flyer03

LaunchEvent_flyer03

LaunchEvent_flyer03.jpg

Running Study Week 2

Hi Everyone – this “2nd week” of run training that starts tomorrow (Sat, Sept 9) is very similar to this past week – just a little more of it – so no podcast audio this week (but we’ll have one next week when the workout changes up a bit).

Your GOAL this coming week is pretty much the same as last week – to complete at least THREE specific workouts:

  • one “interval” workout…
  • one “hill” workout…
  • one “endurance” workout (LSD = long slow distance)

Remember that the objective of intervals is to make you faster – the objective of hills is to make you stronger – and the objective of LSD is to improve your endurance and fat-burning efficiency.

Here is WEEK 2:

  • Sat Sept 9 or Sun Sept 10:
    • 60-70 minute Long Slow Distance (LSD) – “endurance”
      • RPE (rating of perceived exertion) = 5-7 (out of 10)
        • NOTE = be sure to go hard – easy – NOT “medium”
  • Mon Sept 11 or Tues Sept 12:
    • 1 mile easy jog to warm-up
    • 6-7 Intervals – “speed”
    • 60-seconds “fast” (RPE = 7-9)
    • 60-seconds “slow” (RPE (2-3)
      • NOTE = be sure to go hard – easy – NOT “medium”
    • 1 mile easy jog to cool-down
      • NOTE = this is only 6-7 minutes of “hard” effort – so if you want a longer workout, you can run additional “tempo” miles to your level of fitness.
  • Wed Sept 13 or Thurs Sept 14:
    • 1 mile easy jog to warm-up
    • 6-7 Hills – “strength”
    • 60-seconds per UPhill (RPE = 7-9)
    • 60-seconds per DOWNhill (RPE = 7-9)
      • NOTE = be sure to go hard – easy – NOT “medium”
    • 1 mile easy jog to cool-down
      • NOTE = this is only 6-7 minutes of “hard” effort – so if you want a longer workout, you can run additional “tempo” miles to your level of fitness.

Tempo workouts are those “medium hard” efforts that leave us feeling like we had a “good workout” – but they’re not very effective for actual “performance” – so we prefer to run tempo pace (RPE = 6-7) when we want to loosen the legs + free the mind (not for our 3 specific training sessions each week.

That’s all for now – please send Shawn and Julie any questions – and Good Luck training!

Amare Zoom Tonight

Hello Everyone,

We have a SPECIAL GUEST on tonight’s zoom visit! None other than Amare’s Chief Science Officer, Dr. Shawn Talbott! He will do his usual fine work of providing great insight into Amare’s unique Science and Product offering! We start in about an hour from now! Grab a friend and join us!

HERE WE GO! OUR FIRST FULL WEEK OF OUR FOUNDERS LAUNCH!

Each Night – Monday thru Saturday at 8 PM Central Time

Thursday, Sept 7th at 3 PM Central Time

SPECIAL SATURDAY MORNING LEADERS CALL – SEPT 9th

at 10 AM Central Time!

(This will have a different format – STRIVE for LIFE training will be discussed!)

USE SAME ZOOM CODE FOR ALL OF THESE SCHEDULED VISITS

Join from PC, Mac, Linux, iOS or Android: https://zoom.us/j/3900338036

Sincerely hope to see you there! Pat

Or iPhone one-tap :

US: +14086380968,,3900338036# or +16468769923,,3900338036#

Or Telephone:

Dial(for higher quality, dial a number based on your current location):

US: +1 408 638 0968 or +1 646 876 9923

Meeting ID: 390 033 8036

Running Week 1

Hi Everyone – and welcome to the first week of your running program!

Starting tomorrow (Sept 2) – and “running” (ha ha) for 8 weeks until our “race” on October 28 – your GOAL will be to complete THREE specific workouts each week:

  • one “interval” workout…
  • one “hill” workout…
  • one “endurance” workout (LSD = long slow distance)

The objective of intervals is to make you faster – the objective of hills is to make you stronger – and the objective of LSD is to improve your endurance and fat-burning efficiency.

Each week, I will also post a short Audio/Podcast explaining the objectives for the coming week. Workout 1 audio is below:

I will also post each workout to this blog – so here is WEEK 1:

  • Sat Sept 2 or Sun Sept 3:
    • 60-minute Long Slow Distance (LSD) – “endurance”
      • RPE (rating of perceived exertion) = 5-7 (out of 10)
        • NOTE = be sure to go hard – easy – NOT “medium”
  • Mon Sept 4 or Tues Sept 5:
    • 1 mile easy jog to warm-up
    • 5-6 Intervals – “speed”
    • 60-seconds “fast” (RPE = 7-9)
    • 60-seconds “slow” (RPE (2-3)
      • NOTE = be sure to go hard – easy – NOT “medium”
    • 1 mile easy jog to cool-down
      • NOTE = this is only 5-6 minutes of “hard” effort – so if you want a longer workout, you can run additional “tempo” miles to your level of fitness.
  • Wed Sept 6 or Thurs Sept 7:
    • 1 mile easy jog to warm-up
    • 5-6 Hills – “strength”
    • 60-seconds per UPhill (RPE = 7-9)
    • 60-seconds per DOWNhill (RPE = 7-9)
      • NOTE = be sure to go hard – easy – NOT “medium”
    • 1 mile easy jog to cool-down
      • NOTE = this is only 5-6 minutes of “hard” effort – so if you want a longer workout, you can run additional “tempo” miles to your level of fitness.

Tempo workouts are those “medium hard” efforts that leave us feeling like we had a “good workout” – but they’re not very effective for actual “performance” – so we prefer to run tempo pace (RPE = 6-7) when we want to loosen the legs + free the mind (not for our 3 specific training sessions each week).

  • Keep in mind – our Weekly Goal:
    • 1 Interval workout
    • 1 Hill workout
    • 1 LSD workout
    • Other workouts = weights, cross-training, Tempo – can all be added in based on your fitness, time, and motivation.

That’s all for now – please send Shawn and Julie any questions – and Good Luck training!

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