Mid-life microbiota crises: middle age is associated with pervasive neuroimmune alterations that are reversed by targeting the gut microbiome | Molecular Psychiatry

Male middle age is a transitional period where many physiological and psychological changes occur leading to cognitive and behavioural alterations, and a deterioration of brain function. However, the mechanisms underpinning such changes are unclear. The gut microbiome has been implicated as a key mediator in the communication between the gut and the brain, and in the regulation of brain homeostasis, including brain immune cell function. Thus, we tested whether targeting the gut microbiome by prebiotic supplementation may alter microglia activation and brain function in ageing. Male young adult (8 weeks) and middle-aged (10 months) C57BL/6 mice received diet enriched with a prebiotic (10% oligofructose-enriched inulin) or control chow for 14 weeks. Prebiotic supplementation differentially altered the gut microbiota profile in young and middle-aged mice with changes correlating with faecal metabolites. Functionally, this translated into a reversal of stress-induced immune priming in middle-aged mice. In addition, a reduction in ageing-induced infiltration of Ly-6Chi monocytes into the brain coupled with a reversal in ageing-related increases in a subset of activated microglia (Ly-6C+) was observed. Taken together, these data highlight a potential pathway by which targeting the gut microbiome with prebiotics can modulate the peripheral immune response and alter neuroinflammation in middle age. Our data highlight a novel strategy for the amelioration of age-related neuroinflammatory pathologies and brain function.
— Read on www.nature.com/articles/s41380-019-0425-1

Nutra-Ingredients Finalists! (again)…

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NutraIngredients-USA Nominates Amare as a Finalist for the Second Consecutive Year!
The NutraIngredients-USA Awards recognize the “best and brightest in ingredients, finished products, companies, people, and initiatives in the nutrition and dietary supplements industry.”
Amare is a Finalist in the Following Two Categories:
Start-Up of the Year — Amare Global
Probiotic Product of the Year — Kids FundaMentals
This is the second year we’ve been named finalists by NutraIngredients-USA. We were finalists in two categories last yearas well: Start-Up of the Year and Botanical Product of the Year for Mood+.
NutraIngredients-USA Awards winners will be announced in New Orleans, LA, on Monday, June 3, 2019, during a special event.
Read More on Our Blog
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Mental Wellness in Kids

Here is a video covering Mental Wellness specifically for kids that I did with our Amare groups in Hawaii…

Video = https://youtu.be/hWZYDMqzknQ

Slides = Amare Kids Products Zoom 051619

 

Best Protein?

One of the most frequent questions I get from people is about “what is the ‘BEST’ protein” for them to be using.

The answer is – “it depends” on a lot of factors – watch this video to understand how to make the best choice…

…and here are the slides = Protein Deep Dive

Enjoy!

Amare Product Overview Zoom

This video is from May 2, 2019 – and overview of ALL Amare products, including where to download the comprehensive Product Education slide set and the Fundamentals clinical trial.

Enjoy!

 

Project b3 May/June 2019

For this 8-week session, I will post EACH weekly session here in this single article – updated weekly as the sessions are held…

Session #1 = Overview VIDEO = https://youtu.be/KlBki3UqVUo

Session #2 = Body/Brain/Biome concept was a replay (because I was speaking at an event in Chicago that night) – so here is the Session 2 replay (and also here is the Chicago event, just in case you want to see that too)!

Session #3 = Supplementation VIDEO = https://youtu.be/PnDo4ydWQoM

 

 

Mental Wellness in SoCal – May 18

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Join Us in Southern California for Our Welcome Home Event on Saturday, May 18!

We’ve developed the world’s first award-winning gut-brain axis nutrition system to help people optimize their mental wellness. Join us at our Home Office event to find out more and see how you can take yourself to a higher level of mental and physical performance.

Register Now
Date: Saturday, May 18
Time: 10 AM-4 PM
Location: Amare Global Corporate Office
17872 Gillette Avenue, Suite 100
Irvine, CA 92614
Register Now
Featured Speakers
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Hiep Tran
Chief Executive Officer
Founder
Shawn Talbott (image)
Dr. Shawn Talbott
Chief Science Officer
Founding Executive
Rich Higbee (image)
Rich Higbee
President of Sales
Founding Executive
Mike Brown (image)
Mike Brown
Chief Marketing Officer
Founding Executive
Pat Hintze
Founding Wellness Partner
Join us to learn:
  • More about our holistic mental wellness platform of products, programs and community
  • Why the nutrition industry just named us 2018’s Best New Finished Product and nominated us for Start-Up of the Year
  • What you can do to help manage stress, occasional anxiety and feelings of depression holistically and naturally
  • How financial health is crucial to your mental health and how Amare’s unique business model can help you thrive financially
  • About two newest product lines — a gut-brain axis foods system designed to boost your microbiome and a kids line formulated to help kids and teens improve their cognitive performance, and naturally manage stress, occasional anxiety and feelings of depression*
We Can’t Wait to See You at Our Home Office Event on Saturday, May 18!
Register Now
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
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Our mailing address is:

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Irvine, CA 92614

Gut-Brain-Axis & Mental Wellness in Wisconsin (May 9)

Here is the video from our overview in Wisconsin (May 9, 2019) of the impact of the microbiome and the gut-brain-axis on mental wellness – enjoy!

Video on FaceBook

How diet affects brain health and mood, and what to eat to reduce stress and feel good | South China Morning Post

Gut bacteria break down what we eat, creating molecules that communicate with brain neurons, and can produce antioxidants that head off anxiety and Parkinson’s disease; a Mediterranean-like diet lowers the risk of depression.
— Read on www.scmp.com/lifestyle/health-wellness/article/3009483/how-diet-affects-brain-health-and-mood-and-what-eat

Project b3 – Session #2 – Body/Brain/Biome

Tonight I will be speaking about gut-brain-axis and Mental Wellness in Chicago, so I will not be able to do a LIVE session for Project b3 (but we will stream the Chicago event at ZoomwithPat.com so please tune in)!
Instead, please watch this recorded session on the Body-Brain-Biome from our recent research study on Project b3 = https://bestfutureyou.com/2019/02/22/project-b3-research-study-session-2/
This link includes the video presentation and slides for this session #2.
As always, let us know any questions as you’re just completing your first full week of Project b3!