Cell protection by polyphenols

Dr. Shawn Talbott (Ph.D., CNS, LDN, FACSM, FACN, FAIS) has gone from triathlon struggler to gut-brain guru! With a Ph.D. in Nutritional Biochemistry, he's on a mission to boost everyday human performance through the power of natural solutions and the gut-brain axis.

Have you ever wondered why Amare Global’s VitaGBX is so high in polyphenol-rich phytonutrients?

One reason is because they can help to protect delicate neurons (brain cells) from damage – and another is because they can help to improve blood flow to the brain, thus improving delivery of oxygen and nutrients for optimal brain performance.

But – did you also know that polyphenols can activate intracellular protection pathways like Nrf2 (to increase antioxidant enzyme production) AND inhibit inflammatory pathways like NF-KB (to reduce inflammatory cytokine production)?

This means that polyphenol-rich diets and supplements (like VitaGBX) have the potential to not just “protect” cells – but to help cells to actively “protect themselves” whenever they’re exposed to stress. No other multivitamin does what VitaGBX can do…

I though this recent paper (from 16 scientists in 7 countries) about NF-kB signaling by polyphenols was interesting? This research focuses on cancer, but the concept applies to any aspect of improved cellular protection – such as anti-aging effects.

Crit Rev Food Sci Nutr. 2019 Sep 12:1-11. Targeting NF-?B signaling pathway in cancer by dietary polyphenols.

Khan H1, Ullah H1, Castilho PCMF2, Gomila AS3,4, D’Onofrio G5, Filosa R6,7, Wang F8, Nabavi SM9, Daglia M10, Silva AS11,12, Rengasamy KRR13, Ou J14, Zou X15, Xiao J14,15, Cao H16.

Author information

  • 1Department of Pharmacy, Abdul Wali Khan University , Mardan , Pakistan.
  • 2CQM Madeira Chemistry Research Centre, Faculty of Exact Sciences and Engineering, Madeira University , Funchal , Portugal.
  • 3Research Group on Community Nutrition and Oxidative Stress, University of the Balearic Islands , Palma de Mallorca , Spain.
  • 4CIBEROBN (Physiopathology of Obesity and Nutrition, CB12/03/30038), Instituto de Salud Carlos III , Madrid , Spain.
  • 5Department of Medical Sciences, IRCCS “Casa Sollievo della Sofferenza”, Complex Unit of Geriatrics , San Giovanni Rotondo , Italy.
  • 6Department of Experimental Medicine, Università degli Studi della Campania Luigi Vanvitelli , Naples , Italy.
  • 7Consorzio Sannio Tech , Apollosa , Italy.
  • 8College of Food Science and Engineering, Nanjing University of Finance and Economics , Nanjing , China.
  • 9Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences , Tehran , Iran.
  • 10Department of Drug Sciences, Medicinal Chemistry and Pharmaceutical Technology Section, University of Pavia , Pavia , Italy.
  • 11National Institute for Agricultural and Veterinary Research , Vairão , Vila do Conde , Portugal.
  • 12Center for Study in Animal Science (CECA), ICETA, University of Oporto , Oporto , Portugal.
  • 13Department of Bio-resources and Food Science, Konkuk University , Seoul , South Korea.
  • 14Institute of Food Safety and Nutrition, Jinan University , Guangzhou , China.
  • 15Institute of Food Safety and Nutrition, Jiangsu University , Zhenjiang , China.
  • 16College of Food Science, Fujian Agriculture and Forestry University , Fuzhou , Fujian , China.


Being a transcription factor, NF-?B regulates gene expressions involving cell survival and proliferation, drug resistance, metastasis, and angiogenesis. The activation of NF-?B plays a central role in the development of inflammation and cancer. Thus, the down-regulation of NF-?B may be an exciting target in prevention and treatment of cancer. NF-?B could act as a tumor activator or tumor suppressant decided by the site of action (organ). Polyphenols are widely distributed in plant species, consumption of which have been documented to negatively regulate the NF-?B signaling pathway. They depress the phosphorylation of kinases, inhibit NF-?B translocate into the nucleus as well as interfere interactions between NF-?B and DNA. Through inhibition of NF-?B, polyphenols downregulate inflammatory cascade, induce apoptosis and decrease cell proliferation and metastasis. This review highlights the anticancer effects of polyphenols on the basis of NF-?B signaling pathway regulation.


Dietary polyphenols; cancer; nuclear factor-?B; phosphorylation; signaling pathway

About the Author

Exercise physiologist (MS, UMass Amherst) and Nutritional Biochemist (PhD, Rutgers) who studies how lifestyle influences our biochemistry, psychology and behavior - which kind of makes me a "Psycho-Nutritionist"?!?!

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