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Probiotics and Depression

In an outstanding scientific review from Caroline Wallace and Roumen Milev at Queen’s University in Ontario Canada, the effects of probiotics on depressive symptoms in humans is reviewed = https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5319175/

Some highlights from the publication:

  • link between psychiatric disorders and changes in the microbiome
  • majority of the studies found positive results on all measures of depressive symptoms (depending on the specific strain or probiotic, dosing and duration)
  • evidence for probiotics alleviating depressive symptoms is compelling
  • probiotics may reduce depression and improve mood via a variety of complementary mechanisms, including:
    • modulation of stress response
    • increased neurotransmitter production and improved activity
    • reduction in permeability of gastrointestinal lining
    • increased production of brain-derived neurotrophic factor (BDNF), a growth factor crucial for brain plasticity, memory, and neuronal health
    • Reduction in both gastrointestinal inflammation  and neuro-inflammation

Abstract:

Ann Gen Psychiatry. 2017; 16: 14.

The effects of probiotics on depressive symptoms in humans: a systematic review

 

 

Background

Patients suffering from depression experience significant mood, anxiety, and cognitive symptoms. Currently, most antidepressants work by altering neurotransmitter activity in the brain to improve these symptoms. However, in the last decade, research has revealed an extensive bidirectional communication network between the gastrointestinal tract and the central nervous system, referred to as the “gut–brain axis.” Advances in this field have linked psychiatric disorders to changes in the microbiome, making it a potential target for novel antidepressant treatments. The aim of this review is to analyze the current body of research assessing the effects of probiotics, on symptoms of depression in humans.

Methods

A systematic search of five databases was performed and study selection was completed using the preferred reporting items for systematic reviews and meta-analyses process.

Results

Ten studies met criteria and were analyzed for effects on mood, anxiety, and cognition. Five studies assessed mood symptoms, seven studies assessed anxiety symptoms, and three studies assessed cognition. The majority of the studies found positive results on all measures of depressive symptoms; however, the strain of probiotic, the dosing, and duration of treatment varied widely and no studies assessed sleep.

Conclusion

The evidence for probiotics alleviating depressive symptoms is compelling but additional double-blind randomized control trials in clinical populations are warranted to further assess efficacy.

Keywords: Depression, Anxiety, Probiotics, Gut–brain axis, Microbiome, Systematic review

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