Good article in the WSJ about the development of Mounjaro – the latest in a line of drugs known as “GLP-1 agonists” – which are synthetic versions of the natural GLP-1 hormone that our guts produce to stimulate insulin production, lower blood sugar, and control appetite.
From the article…
“Mounjaro could be one of the highest-selling drugs of all time with annual sales exceeding $25 billion. Novo’s Ozempic and Wegovy brought in close to $10 billion last year”
“The drug Mounjaro helped a typical person with obesity who weighed 230 pounds lose up to 50 pounds during a test period of nearly 17 months.”
These GLP-1 drugs can sometimes help obese subjects lose around 20% of the body weight (which is still no more than 3lbs per month) – but many people cannot tolerate the nausea and other (sometimes serious) side effects of the drugs. Importantly, almost everyone gains the weight back when they stop taking the drugs.
As I’ve written about many times on this blog and in my books, there are a number of very safe and extremely effective natural ways to encourage your gut to make more of its own GLP-1 (to control appetite and encourage fat loss) – and balance insulin/glucose (which helps your mood and metabolism) – and even help you avoid the dreaded “rebound” weight regain after you’ve lost it (by improving fat-burning – aka “thermogenesis” in brown fat).
Some of the interesting ingredients we’re using include specific strains of probiotic bacteria (DR7 and BPL1) and prebiotic fibers (acacia and RG-1), as well as spices and plant extracts (orange peel, glomerata fruit, grains of paradise) – which have all been shown in numerous clinical trials.
We have a pilot study underway right now where we have thousands of people using these natural approaches to lose pounds and inches by shifting their metabolism toward fat loss and muscle gain. Participants are not only looking better with improved body composition – but are feeling better with improved mood, higher energy, and better stress resilience.
Imagine that – natural approaches that harness your body’s own metabolic machinery – to help you lose weight and feel great – without synthetic-driven side effects. I only hope that more people can learn about them…