Microbiome and Aging

Yet another interesting article outlining the many ways in which the human microbiome governs so many aspects of human health – in this case, the aging process.

Gut microbiota and aging

Zongxin Ling, Xia Liu, Yiwen Cheng, Xiumei Yan & Shaochang Wu (2020) 

Critical Reviews in Food Science and Nutrition, DOI: 10.1080/10408398.2020.1867054

https://www.tandfonline.com/doi/full/10.1080/10408398.2020.1867054

Abstract

Aging is characterized by the functional decline of tissues and organs and increased risk of aging-associated disorders, which pose major societal challenges and are a public health priority. Despite extensive human genetics studies, limited progress has been made linking genetics with aging. There is a growing realization that the altered assembly, structure and dynamics of the gut microbiota actively participate in the aging process. Age-related microbial dysbiosis is involved in reshaping immune responses during aging, which manifest as immunosenescence (insufficiency) and inflammaging (over-reaction) that accompany many age-associated enteric and extraenteric diseases. The gut microbiota can be regulated, suggesting a potential target for aging interventions. This review summarizes recent findings on the physiological succession of gut microbiota across the life-cycle, the roles and mechanisms of gut microbiota in healthy aging, alterations of gut microbiota and aging-associated diseases, and the gut microbiota-targeted anti-aging strategies.

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