Cambridge England Nrf2 Conference – Day 1 Highlights

I’m at the Nrf2 Science conference at Cambridge University for the next couple of days. I present my poster on “Phytonutrient activation of the Nrf2 pathway” later today.

Here are a few highlights from the presentations yesterday (Day 1):

From Thomas Kensler – University of Pittsburgh:

  • Nrf2 activation is important for a wide variety of cell-protection functions, including:
    • Liver Protection (aflatoxin-induced liver cancer and acetaminophen/Tylenol-induced liver damage)
    • Air pollution (via glutathione-related conjugation of toxins)
    • Estrogen-induced toxicity (DNA damage)
    • Mammary (breast) stem cell regeneration
    • A wide range of cell-protection benefits, including:
      • Damage Prevention
      • Damage Control
      • Cell Regeneration

Another great presentation was delivered by Dr. Masayuki Yamamoto from Tohoku University in Japan – here are some highlights:

  • Nrf2 responds to intra-cellular stress from a variety of sources (ER, lysosome, autophagosomes)…
  • Phase II enzyme activation by Nrf2 is essential for cancer prevention – especially for air pollution-induced cancer (protection by glutathione-related enzymes and others)
  • Nrf2 activation has anti-diabetic effects by improving insulin sensitivity and controlling blood glucose levels.
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  1. tom

     /  February 3, 2015

    I just listened to a lifevantage conference call and it seems they think their protandim product is leading technology. Anyone interested in Nrf2 synergy through protandim there?

  1. Cellular Stress and Cellular Balance are HOT Areas of Research | Shawn Talbott

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