Cambridge England Nrf2 Conference – Day 1 Highlights

I’m at the Nrf2 Science conference at Cambridge University for the next couple of days. I present my poster on “Phytonutrient activation of the Nrf2 pathway” later today.

Here are a few highlights from the presentations yesterday (Day 1):

From Thomas Kensler – University of Pittsburgh:

  • Nrf2 activation is important for a wide variety of cell-protection functions, including:
    • Liver Protection (aflatoxin-induced liver cancer and acetaminophen/Tylenol-induced liver damage)
    • Air pollution (via glutathione-related conjugation of toxins)
    • Estrogen-induced toxicity (DNA damage)
    • Mammary (breast) stem cell regeneration
    • A wide range of cell-protection benefits, including:
      • Damage Prevention
      • Damage Control
      • Cell Regeneration

Another great presentation was delivered by Dr. Masayuki Yamamoto from Tohoku University in Japan – here are some highlights:

  • Nrf2 responds to intra-cellular stress from a variety of sources (ER, lysosome, autophagosomes)…
  • Phase II enzyme activation by Nrf2 is essential for cancer prevention – especially for air pollution-induced cancer (protection by glutathione-related enzymes and others)
  • Nrf2 activation has anti-diabetic effects by improving insulin sensitivity and controlling blood glucose levels.
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  1. tom

     /  February 3, 2015

    I just listened to a lifevantage conference call and it seems they think their protandim product is leading technology. Anyone interested in Nrf2 synergy through protandim there?

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