I’m at the Nrf2 Science conference at Cambridge University for the next couple of days. I present my poster on “Phytonutrient activation of the Nrf2 pathway” later today.
Here are a few highlights from the presentations yesterday (Day 1):
From Thomas Kensler – University of Pittsburgh:
- Nrf2 activation is important for a wide variety of cell-protection functions, including:
- Liver Protection (aflatoxin-induced liver cancer and acetaminophen/Tylenol-induced liver damage)
- Air pollution (via glutathione-related conjugation of toxins)
- Estrogen-induced toxicity (DNA damage)
- Mammary (breast) stem cell regeneration
- A wide range of cell-protection benefits, including:
- Damage Prevention
- Damage Control
- Cell Regeneration
Another great presentation was delivered by Dr. Masayuki Yamamoto from Tohoku University in Japan – here are some highlights:
- Nrf2 responds to intra-cellular stress from a variety of sources (ER, lysosome, autophagosomes)…
- Phase II enzyme activation by Nrf2 is essential for cancer prevention – especially for air pollution-induced cancer (protection by glutathione-related enzymes and others)
- Nrf2 activation has anti-diabetic effects by improving insulin sensitivity and controlling blood glucose levels.