The Metabolic Memory

Dr. Shawn Talbott (Ph.D., CNS, LDN, FACSM, FACN, FAIS) has gone from triathlon struggler to gut-brain guru! With a Ph.D. in Nutritional Biochemistry, he's on a mission to boost everyday human performance through the power of natural solutions and the gut-brain axis.

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Here’s another excerpt from my 10th book, The Secret of Vigor – How to Overcome Burnout, Restore Biochemical Balance and Reclaim Your Natural Energy

Some of the most popular New Year’s resolutions every year are:
*Lose Weight
*Get in Shape
*Reduce Stress
*Get Healthier
*Win the Lottery

The Secret of Vigor can help you with 4 out of 5 of the most popular resolution goals, so I’ll be posting excerpts from the book for the next several weeks – so please stay tuned for each installment.

If you simply can’t wait, then you can certainly get a copy at or at your favorite library or bookstore.

The Metabolic Memory
One of the biggest problems with the glycated proteins called AGEs, as indicated above, is that they persist in tissues for a long time after their initial creation. This allows AGE-damaged cells and tissues to continue causing damage to surrounding tissues—even long after you take steps to stabilize glucose. This effect is sometimes referred to as “metabolic memory,” because it appears as if the individual tissues that have been influenced by AGEs will “remember” the damaging effects of elevated glucose and continue to send oxidative and inflammatory signals to surrounding tissues and throughout the body.

Studies have shown that the longer that glucose levels remain uncontrolled (elevated), the more AGEs are created—and the longer that oxidative and inflammatory signals will persist even after glucose levels are lowered. Furthermore, the faster that glucose levels are returned to normal levels, the faster those damaging oxidative/inflammatory signals dissipate as well.

Combining antioxidant/anti-inflammatory agents with glucose-lowering interventions has been shown to almost completely interrupt AGE-related tissue dysfunction (particularly in endothelial tissues, such as blood vessels). Glucose-lowering interventions can range from reducing your dietary intake of highly refined carbohydrates, such as white bread, to combining whole-grain carbohydrates with healthy fats and fiber to using specific glucose-control dietary supplements.

About the Author

Exercise physiologist (MS, UMass Amherst) and Nutritional Biochemist (PhD, Rutgers) who studies how lifestyle influences our biochemistry, psychology and behavior - which kind of makes me a "Psycho-Nutritionist"?!?!

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